Jane Irwin Harrison (1804 - 1845) was the First Lady of the United States for a very brief period. She was married to William Henry Harrison Jr. William was the son of William Henry Harrison, ninth President of the United States. As the daughter-in-law of the president, she acted as the First Lady for about a month in 1841. She acted as his official hostess during his brief tenure in office, which lasted for a month in 1841. President’s wife Anna Harrison was very ill, and she could not go out of their home in Ohio, when her husband moved to take up the presidency.