Pomeroon-Supenaam (Region 2) is a region of Esequiban Guyana, a territory in dispute by Guyana and Venezuela. Venezuela claims the territory as part of Delta Amacuro state. The regional capital is Anna Regina.
The region is in the north of the country. It has an area of 6,195 km². As of the 2012 census, 46,810 people lived there. It borders the Atlantic Ocean to the north, the region of Essequibo Islands-West Demerara to the east, the region of Cuyuni-Mazaruni to the south and the region of Barima-Waini to the west.