||The English used in this article or section may not be easy for everybody to understand. (October 2011)|
|Group:||Group V ((-)ssRNA)|
The Orthomyxoviridae (orthos, Greek for "straight"; myxa, Greek for "mucus") are a family of RNA viruses. They include five genera: Influenzavirus A, Influenzavirus B, Influenzavirus C, Thogotovirus and Isavirus. The first three genera contain viruses that cause influenza in vertebrates, including birds (see also avian influenza), humans, and other mammals. Isaviruses infect salmon; thogotoviruses infect vertebrates and invertebrates, such as mosquitoes and sea lice.
- Influenzavirus A cause of all flu pandemics and infect humans, other mammals and birds
- Influenzavirus B infect humans and seals
- Influenzavirus C infect humans and pigs
Types[change | change source]
There are three genera of influenza virus: Influenzavirus A, Influenzavirus B and Influenzavirus C. Each genus includes only one species, or type: Influenza A virus, Influenza B virus, and Influenza C virus, respectively. Influenza A and C infect multiple species, while influenza B almost exclusively infects humans.
Influenza A[change | change source]
Influenza A viruses are further classified, based on the viral surface proteins hemagglutinin (HA or H) and neuraminidase (NA or N). Sixteen H subtypes (or serotypes) and nine N subtypes of influenza A virus have been identified.
Further variation exists; thus, specific influenza strain isolates are identified by a standard nomenclature specifying virus type, geographical location where first isolated, sequential number of isolation, year of isolation, and HA and NA subtype.
Examples of the nomenclature are:
- A/Moscow/10/99 (H3N2)
- B/Hong Kong/330/2001
The type A viruses are the most virulent human pathogens among the three influenza types and causes the most severe disease. The serotypes that have been confirmed in humans, ordered by the number of known human pandemic deaths, are:
- H1N1 caused "Spanish Flu".
- H2N2 caused "Asian Flu".
- H3N2 caused "Hong Kong Flu".
- H5N1 is a pandemic threat in 2006-7 flu season.
- H7N7 has unusual zoonotic potential.
- H1N2 is endemic in humans and pigs.
- H9N2, H7N2, H7N3, H10N7.
|Name||Year||Deaths (millions)||Subtype involved|
|Asiatic (Russian) Flu||1889-90||1||possibly H2N2|
|Hong Kong Flu||1968-69||0.75||H3N2|
Influenza B[change | change source]
Influenza B virus is almost exclusively a human pathogen, and is less common than influenza A. The only other animal known to be susceptible to influenza B infection is the seal. This type of influenza mutates at a rate 2-3 times lower than type A and consequently is less genetically diverse, with only one influenza B serotype. As a result of this lack of antigenic diversity, a degree of immunity to influenza B is usually acquired at an early age. However, influenza B mutates enough that lasting immunity is not possible. This reduced rate of antigenic change, combined with its limited host range (inhibiting cross species antigenic shift), ensures that pandemics of influenza B do not occur.
Influenza C[change | change source]
The influenza C virus infects humans and pigs, and can cause severe illness and local epidemics. However, influenza C is less common than the other types and usually seems to cause mild disease in children.
References[change | change source]
- International Committee on Taxonomy of Viruses Index of Viruses - Orthomyxoviridae (2006). In: ICTVdB - The Universal Virus Database, version 4. Büchen-Osmond, C (Ed), Columbia University, New York, USA.
- Büchen-Osmond, C., ed. (2006). "Index of Viruses - Orthomyxoviridae (2006). In: ICTVdB - The Universal Virus Database, version 4". Columbia University, New York, USA. http://www.ncbi.nlm.nih.gov/ICTVdb/Ictv/fs_index.htm.
- Jones LD, Nuttall PA (1989). "Non-viraemic transmission of Thogoto virus: influence of time and distance". Trans. R. Soc. Trop. Med. Hyg. 83 (5): 712–4. . .
- Barry Ely (1999). "Infectious Salmon Anaemia". Mill Hill Essays. National Institute for Medical Research. http://www.nimr.mrc.ac.uk/MillHillEssays/1999/isa.htm. Retrieved 2007-09-14.
- Raynard RS, Murray AG, Gregory A (2001). "Infectious salmon anaemia virus in wild fish from Scotland". Dis. Aquat. Org. 46 (2): 93–100. . .
- Hay A, Gregory V, Douglas A, Lin Y (2001-12-29). "The evolution of human influenza viruses" (PDF). Philos Trans R Soc Lond B Biol Sci 356 (1416): 1861–70. . . http://www.journals.royalsoc.ac.uk/media/hf0bujxwvrcxd7nwdrwq/contributions/l/x/y/v/lxyv2p8w45geev90.pdf.
- "Avian Influenza (Bird Flu)". Centers for Disease Control and Prevention. http://www.cdc.gov/flu/avian/. Retrieved 2007-09-15.
- Atkinson W, Hamborsky J, McIntyre L, Wolfe S, ed. (2007). Epidemiology and Prevention of Vaccine-Preventable Diseases (10th ed.). Washington DC: Centers for Disease Control and Prevention. http://www.cdc.gov/vaccines/pubs/pinkbook/pink-chapters.htm.
- "Avian Influenza (Bird Flu): Implications for Human Disease". Center for Infectious Disease Research & Policy, University of Minnesota. 2007-06-27. http://www.cidrap.umn.edu/cidrap/content/influenza/avianflu/biofacts/avflu_human.html. Retrieved 2007-09-14.
- Fouchier R, Schneeberger P, Rozendaal F, Broekman J, Kemink S, Munster V, Kuiken T, Rimmelzwaan G, Schutten M, Van Doornum G, Koch G, Bosman A, Koopmans M, Osterhaus A (2004). "Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome". Proc Natl Acad Sci USA 101 (5): 1356–61. . .
- Hilleman M (2002-08-19). "Realities and enigmas of human viral influenza: pathogenesis, epidemiology and control". Vaccine 20 (25-26): 3068–87. . .
- Osterhaus A, Rimmelzwaan G, Martina B, Bestebroer T, Fouchier R (2000). "Influenza B virus in seals". Science 288 (5468): 1051–3. . .
- Nobusawa E, Sato K (April 2006). "Comparison of the mutation rates of human influenza A and B viruses". J Virol 80 (7): 3675–8. . .
- Webster R, Bean W, Gorman O, Chambers T, Kawaoka Y (1992-03-01). "Evolution and ecology of influenza A viruses". Microbiol Rev 56 (1): 152–79. . http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=1579108.
- Zambon M (November 1999). "Epidemiology and pathogenesis of influenza". J Antimicrob Chemother 44 Suppl B: 3–9. . . http://jac.oxfordjournals.org/cgi/reprint/44/suppl_2/3.
- Matsuzaki Y, Sugawara K, Mizuta K, Tsuchiya E, Muraki Y, Hongo S, Suzuki H, Nakamura K (2002). "Antigenic and genetic characterization of influenza C viruses which caused two outbreaks in Yamagata City, Japan, in 1996 and 1998". J Clin Microbiol 40 (2): 422–9. . . http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=11825952.
- Matsuzaki Y, Katsushima N, Nagai Y, Shoji M, Itagaki T, Sakamoto M, Kitaoka S, Mizuta K, Nishimura H (May 1, 2006). "Clinical features of influenza C virus infection in children". J Infect Dis 193 (9): 1229–35. . .
- Katagiri S, Ohizumi A, Homma M (July 1983). "An outbreak of type C influenza in a children's home". J Infect Dis 148 (1): 51–6. .
Other websites[change | change source]
- BioHealthBase Bioinformatics Resource Center Database of influenza genomic sequences and related information.