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Don can stand for different concepts:
- It is one of the main rivers in Russia, see Don River (Russia)
- It is a name, see Donald (given name) for people with this name
- Don (honorific), an honorific used in Spanish, Portuguese, Italian and Filipino
- 2,5-Dimethoxy-4-nitroamphetamine is abbreviated DON; it is a hallucinogen
- Vomitoxin, also known as DON, is a toxin produced by different fungi
- 6-Diazo-5-oxo-L-norleucin, is an amino acid, that is tested as a chemotherapy against cancer. It is known as DON.
- Nitrogen is sometimes referred to as DON
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