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A teratogen is a substance that can cause congenital defects. Many things can be teratogens, including some chemicals, medications, and infectious diseases.

About 7% of all congenital disorders are caused by teratogens.[1][2]p.23-3

Types of teratogens[change | change source]

Alcohol and illegal drugs[change | change source]

Alcohol is the most common cause of congenital disorders that can be prevented.[3] Alcohol is poisonous to a fetus and can cause brain damage.[4] Drinking alcohol while pregnant can cause the fetus to get fetal alcohol syndrome.[3]

Illegal drugs, like heroin and cocaine, are also poisonous to the fetus and can cause many different congenital problems. For example, cocaine use during pregnancy can cause microcephaly (a smaller head size than usual) and problems with the way the fetus's urinary system and genitals grow.[1]

Medications[change | change source]

Baby born to a mother who took thalidomide while pregnant

Some medications can also hurt the fetus if its mother takes them while she is pregnant. For example:[1][2]p.23-6

Before the 1960s, many countries did not have rules about testing medications for their effects on fetuses.[5] This changed partly because of thalidomide. This medication was given to pregnant women for nausea in the 1950s and 1960s. Between 1956 and 1962, more than 10,000 children in 46 different countries were born with birth defects, like arms and legs that had not grown.[6] Thalidomide had not been tested well enough before it started being prescribed.[6] Now, many countries require more testing before a medication can be said to be safe during pregnancy.[5]

Infections[change | change source]

This baby was born with cataracts (cloudy white lenses in the eyes) caused by rubella

If a woman gets an infection while she is pregnant, sometimes the infection can affect her fetus. The placenta protects the fetus from many different viruses, bacteria, and other pathogens that cause infections. However, some pathogens can get through the placenta and infect the fetus. This is called vertical transmission. Some of these infections can cause birth defects.

Examples of infections that can cause birth defects include:

Chemicals[change | change source]

Some chemicals can cause birth defects, if a pregnant woman is exposed to enough of them. For example:[11]

  • Lead: If a woman ever had lead poisoning, she can pass lead on to her fetus, even if she is not exposed to lead while she is pregnant. This happens because most lead is stored in a person's bones and can come out into the bloodstream many years later. Lead can cause miscarriage and stillbirth as well as birth defects.
  • Mercury: High levels of mercury can cause brain damage in fetuses.

Other things[change | change source]

High levels of ionizing radiation can cause birth defects.[2]p.23-8

Things that are not teratogens[change | change source]

Examples of things that do not cause birth defects include:[11]

References[change | change source]

  1. 1.0 1.1 1.2 "Things to Avoid During Pregnancy: Teratogens". AboutKidsHealth. The Hospital for Sick Children. http://www.aboutkidshealth.ca/en/resourcecentres/pregnancybabies/pregnancy/healthcareinpregnancy/pages/things-to-avoid-during-pregnancy-teratogens.aspx. Retrieved February 17, 2016.
  2. 2.0 2.1 2.2 Chung, Wendy (2004). "Teratogens and Their Effects". In Theodore H. Tulchinsky; Elena A. Varavikova (eds.). The New Public Health: An Introduction for the 21st Century. New York: Columbia University Press. ISBN 978-0127033501.
  3. 3.0 3.1 "Facts about FASDs". cdc.gov. United States Centers for Disease Control and Prevention (CDC). April 16, 2015. http://www.cdc.gov/ncbddd/fasd/facts.html. Retrieved February 14, 2016.
  4. "Fetal Alcohol Syndrome". ncbi.nlm.nih.gov. United States National Library of Medicine. http://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0024268/. Retrieved December 28, 2015.
  5. 5.0 5.1 Tantibanchachai, Chanapa (January 22, 2014). "Teratogens". The Embryo Project Encyclopedia. Arizona State University. ISSN 1940-5030. https://embryo.asu.edu/pages/teratogens. Retrieved February 14, 2016.
  6. 6.0 6.1 Bren L (February 28, 2001). "Frances Oldham Kelsey: FDA Medical Reviewer Leaves Her Mark on History". FDA Consumer (U.S. Food and Drug Administration). http://permanent.access.gpo.gov/lps1609/www.fda.gov/fdac/features/2001/201_kelsey.html.
  7. "STDs during Pregnancy – CDC Fact Sheet". CDC.gov. United States Centers for Disease Control and Prevention. February 3, 2016. http://www.cdc.gov/std/pregnancy/stdfact-pregnancy.htm. Retrieved February 9, 2016.
  8. Torgerson PR; Mastroiacovo P 2013. "The global burden of congenital toxoplasmosis: a systematic review". Bulletin of the World Health Organization 91 (7): 501–508. doi:10.2471/BLT.12.111732. ISSN 0042-9686. PMID 23825877.
  9. Boussault P; Boralevi F; et al. 2007. "Chronic varicella-zoster skin infection complicating the congenital varicella syndrome". Pediatr Dermatol 24 (4): 429–32. doi:10.1111/j.1525-1470.2007.00471.x. PMID 17845179. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0736-8046&date=2007&volume=24&issue=4&spage=429.
  10. McLean, Huong; Redd, Susan; et al. (April 1, 2014). "Chapter 15: Congenital Rubella Syndrome. In “Manual for Surveillance of Vaccine-Preventable Diseases”". CDC.gov. United States Centers for Disease Control and Prevention. http://www.cdc.gov/vaccines/pubs/surv-manual/chpt15-crs.html. Retrieved February 10, 2016.
  11. 11.0 11.1 Gilbert-Barness E 2010. "Teratogenic Causes of Malformations". Annals of Clinical & Laboratory Science (Association of Clinical Scientists, Inc.) 40 (2): 99-114. http://www.annclinlabsci.org/content/40/2/99.full. Retrieved February 2, 2016.