Ludwigshafen on the Rhine is to Mannheim the second largest city of the Metropolregion Rhein-Neckar.
Ludwigshafen is independent of the local district government, but is administrative seat of the surrounding district.
As one of the five upper centers of the country Rhineland-Palatinate Ludwigshafen forms the core of the European Metropolregion Rhine Neckar triangle together with its neighbour city of Baden-Wuerttemberg Mannheim. Further nearer-lying large cities are Heidelberg (about 25 km southeast), Karlsruhe (about 50 km south) and Mainz (about 60 km north).
The number of inhabitants of the city Ludwigshafen on the Rhine exceeded the 100.000 by the year 1925 It has about 160,000 inhabitants and lives mostly on the chemical industry.