Aspartic acid

Aspartic acid
Ball-and-stick model	Space-filling model
Names
	IUPAC name Trivial: Aspartic acid; Systematic: 2-Aminobutanedioic acid;
	Other names Aminosuccinic acid; Asparagic acid; Asparaginic acid;
Identifiers
CAS Number	L: 56-84-8 ; D/L: 617-45-8 ; D: 1783-96-6 ;
3D model (JSmol)	L: Interactive image; D: Interactive image; L Zwitterion: Interactive image; L Deprotonated zwitterion (aspartate): Interactive image;
ChEBI	L: CHEBI:17053 ; D/L: CHEBI:22660 ; D: CHEBI:17364 ;
ChEMBL	L: ChEMBL274323 ;
ChemSpider	L: 5745 ; D/L: 411 ; D: 75697 ;
DrugBank	L: DB00128 ;
ECHA InfoCard	100.000.265
EC Number	L: 200-291-6;
KEGG	D/L: C16433 ;
PubChem CID	L: 5960; D/L: 424; D: 83887;
UNII	L: 30KYC7MIAI ; D/L: 28XF4669EP ; D: 4SR0Q8YD1X ;
CompTox Dashboard (EPA)	L: DTXSID7022621 ;
	SMILES L: C([C@@H](C(=O)O)N)C(=O)O; D/L: C(C(C(=O)O)N)C(=O)O; D: C([C@H](C(=O)O)N)C(=O)O; L Zwitterion: C(C(C(=O)[O-])[NH3+])C(=O)O; L Deprotonated zwitterion (aspartate): C(C(C(=O)[O-])[NH3+])C(=O)[O-];
Properties
Chemical formula	C4H7NO4
Molar mass	133.10 g·mol−1
Appearance	colourless crystals
Density	1.7 g/cm3
Melting point	270 °C (518 °F; 543 K)
Boiling point	324 °C (615 °F; 597 K) (decomposes)
Solubility in water	4.5 g/L
Acidity (pKa)	1.99 (α-carboxyl; H2O); 3.90 (side chain; H2O); 9.90 (amino; H2O);
Conjugate base	Aspartate
Magnetic susceptibility (χ)	-64.2·10−6 cm3/mol
Hazards
	1 1 0
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Aspartic acid (symbol Asp or D;^[4] is an α-amino acid that is used in the biosynthesis of proteins.^[5] Like all other amino acids, it contains an amino group and a carboxylic acid. Aspartic acid has an acidic side chain (CH₂COOH) which reacts with other amino acids, enzymes and proteins in the body.^[5]

It is a non-essential amino acid in humans, meaning the body can make it as needed. It is encoded by the codons GAU and GAC.

D-Aspartate is one of two D-amino acids commonly found in mammals.^[3]

References[change | change source]

↑ Budavari, Susan; Co, Merck (1989). "862. Aspartic acid". The Merck Index (11th ed.). p. 132. ISBN 978-0-911910-28-5.
↑ "ICSC 1439 - L-ASPARTIC ACID". inchem.org.
↑ Haynes, William M., ed. (2016). CRC Handbook of Chemistry and Physics (97th ed.). CRC Press. pp. 5–89. ISBN 978-1498754286.
↑ "Nomenclature and Symbolism for Amino Acids and Peptides". IUPAC-IUB Joint Commission on Biochemical Nomenclature. 1983. Archived from the original on 9 October 2008. Retrieved 5 March 2018.
↑ ^5.0 ^5.1 G., Voet, Judith; W., Pratt, Charlotte (2016-02-29). Fundamentals of biochemistry : life at the molecular level. ISBN 9781118918401. OCLC 910538334.{{cite book}}: CS1 maint: multiple names: authors list (link)

[merck-1] Budavari, Susan; Co, Merck (1989). "862. Aspartic acid". The Merck Index (11th ed.). p. 132. ISBN 978-0-911910-28-5.

[2] "ICSC 1439 - L-ASPARTIC ACID". inchem.org.

[CRC97-3] Haynes, William M., ed. (2016). CRC Handbook of Chemistry and Physics (97th ed.). CRC Press. pp. 5–89. ISBN 978-1498754286.

[4] "Nomenclature and Symbolism for Amino Acids and Peptides". IUPAC-IUB Joint Commission on Biochemical Nomenclature. 1983. Archived from the original on 9 October 2008. Retrieved 5 March 2018.

[:1-5] 5.0 ^5.1 G., Voet, Judith; W., Pratt, Charlotte (2016-02-29). Fundamentals of biochemistry : life at the molecular level. ISBN 9781118918401. OCLC 910538334.{{cite book}}: CS1 maint: multiple names: authors list (link)

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