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Neurodegeneration is the progressive loss of structure or function of neurons, including death of neurons.
Such diseases are incurable, resulting in progressive degeneration and/or death of neuron cells.
There are many parallels between different neurodegenerative disorders including atypical protein assemblies as well as induced cell death. Neurodegeneration can be found in many different levels of neuronal circuitry ranging from molecular to systemic.
References[change | change source]
- "What is Neurodegenerative Disease?". JPND Research. JPND Research. Retrieved February 7, 2015. CS1 maint: discouraged parameter (link)
- Rubinsztein DC (October 2006). "The roles of intracellular protein-degradation pathways in neurodegeneration". Nature. 443 (7113): 780–6. Bibcode:2006Natur.443..780R. doi:10.1038/nature05291. PMID 17051204.
- Bredesen DE, Rao RV, Mehlen P (October 2006). "Cell death in the nervous system". Nature. 443 (7113): 796–802. Bibcode:2006Natur.443..796B. doi:10.1038/nature05293. PMC 3970704. PMID 17051206.