Oliver Smithies

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Oliver Smithies
Born(1925-06-23)June 23, 1925
DiedJanuary 10, 2017(2017-01-10) (aged 91)
NationalityBritish, American
Alma materBalliol College, University of Oxford
Known forGel electrophoresis, gene targeting
AwardsNobel Prize in Physiology or Medicine (2007)
Scientific career
FieldsBiochemistry, genetics
InstitutionsUniversity of Toronto
University of Wisconsin–Madison
University of North Carolina at Chapel Hill

Oliver Smithies (23 June 1925 – 10 January 2017) was a British-American geneticist and Nobel laureate,[1]

He invented gel electrophoresis in 1955,[2] which is now one of the basic techniques of biochemistry and molecular biology.

Much later, he worked on the technique of homologous recombination of transgenic DNA with genomic DNA. This is the most reliable method of altering animal genomes at present, and the technique behind gene targeting and knockout mice.

Martin Evans and Mario Capecchi were also working on this idea, and they were jointly awarded the Nobel Prize in Physiology or Medicine for 2007.

References[change | change source]

  1. "The Nobel Prize in Physiology or Medicine 2007". The Nobel Foundation. Retrieved 2007-10-08.
  2. Smithies, Oliver (December 1955). "Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults". The Biochemical Journal. 61 (4): 629–641. doi:10.1042/bj0610629. ISSN 0264-6021. PMC 1215845. PMID 13276348.