Roderick MacKinnon

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Roderick MacKinnon
Born(1956-02-19)19 February 1956
NationalityUnited States
Alma materBrandeis University
AwardsNobel Prize in Chemistry (2003),
Albert Lasker Award for Basic Medical Research (1999),
Louisa Gross Horwitz Prize (2003)
Scientific career

Roderick MacKinnon (born 19 February 1956) is a professor of Molecular Neurobiology and Biophysics at Rockefeller University. He won the Nobel Prize in Chemistry together with Peter Agre in 2003 for his work on the structure and operation of ion channels.[1][2][3]

Biography[change | change source]

Early life and education[change | change source]

MacKinnon was born in Burlington, Massachusetts and initially attended the University of Massachusetts Boston. MacKinnon then transferred to Brandeis University after one year, and there he received a bachelor's degree in biochemistry in 1978, studying calcium transport through the cell membrane for his honors thesis in Christopher Miller's laboratory. It was also at Brandeis where MacKinnon met his future wife and working-colleague Alice Lee.[4]

After receiving his degree from Brandeis, MacKinnon entered medical school at Tufts University.[3] He got his M.D. in 1982 and received training in Internal Medicine at Beth Israel Hospital in Boston. He did not feel satisfied enough with the medical profession, so in 1986 he returned to Christopher Miller's laboratory at Brandeis for postdoctoral studies.[4]

Career[change | change source]

In 1989 he was appointed assistant professor at Harvard University where he studied the interaction of the potassium channel with a specific toxin taken from scorpion venom. He learned how to purify proteins and to use X-ray crystallography. In 1996, he moved to Rockefeller University as a professor and head of the Laboratory of Molecular Neurobiology and Biophysics. There, he started to work on the structure of the potassium channel. These channels are of particular importance to the nervous system and the heart. The channels enable potassium ions to cross the cell membrane.

Scientific contributions[change | change source]

Potassium channels demonstrate a strange activity. They permit the passage of potassium ions, but they do not allow the passage of the much smaller sodium ions. Before MacKinnon's work, the detailed molecular architecture of potassium channels and the exact means by which they conduct ions was unknown. In 1998, despite barriers to the structural study of integral membrane proteins that had stopped most attempts for decades, MacKinnon and colleagues determined the three-dimensional molecular structure of a potassium channel from bacteria with X-ray crystallography. With this structure and other biochemical experiments, MacKinnon and colleagues were able to explain the exact mechanism by which potassium channel selectivity occurs.[5][6]

His prize-winning research was conducted primarily at the Cornell High Energy Synchrotron Source of Cornell University, and at the National Synchrotron Light Source of Brookhaven National Laboratory.[7]

Awards and distinctions[change | change source]

References[change | change source]

  1. "2003 Nobel Prize in Chemistry Awarded to Researcher Roderick MacKinnon". Brookhaven National Labs. October 8, 2003. Archived from the original on 20 May 2010. Retrieved 11 February 2010.
  2. "Nobel Prize honors Rockefeller University scientist Roderick MacKinnon for revealing process of electrical signaling in humans and other living organisms". The Rockefeller University. October 8, 2003. Archived from the original on 9 June 2010. Retrieved 11 February 2010.
  3. 3.0 3.1 Birmingham K (June 2001). "Rod MacKinnon". Nat. Med. 7 (6): 648. doi:10.1038/89005. PMID 11385491. S2CID 21231263.
  4. 4.0 4.1 MacKinnon, Roderick (October 2003). Tore Frängsmyr (ed.). The Nobel Prizes 2003. Stockholm, Sweden: Nobel Foundation. Retrieved 11 February 2010.
  5. MacKinnon, Roderick; Cohen, Steven L.; Kuo, Anling; Lee, Alice; Chait, Brian T. (1998-04-03). "Structural Conservation in Prokaryotic and Eukaryotic Potassium Channels". Science. 280 (5360): 106–109. doi:10.1126/science.280.5360.106. ISSN 0036-8075. PMID 9525854.
  6. Doyle, Declan A.; Cabral, João Morais; Pfuetzner, Richard A.; Kuo, Anling; Gulbis, Jacqueline M.; Cohen, Steven L.; Chait, Brian T.; MacKinnon, Roderick (1998-04-03). "The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity". Science. 280 (5360): 69–77. doi:10.1126/science.280.5360.69. ISSN 0036-8075. PMID 9525859.
  7. "The Chemistry of the Cell". Brookhaven National Lab. Archived from the original on 28 May 2010. Retrieved 13 March 2010.
  8. "Newcomb Cleveland Prize Recipients". AAAS. Archived from the original on 23 October 2012. Retrieved 13 March 2010.
  9. "W. ALDEN SPENCER LECTURE". Columbia University. Retrieved 13 March 2010.
  10. "Albert Lasker Basic Medical Research Award". LASKER FOUNDATION. 2009. Archived from the original on 16 July 2010. Retrieved 12 February 2010.
  11. 11.0 11.1 "Roderick MacKinnon elected to U.S. National Academy of Sciences". The Rockefeller University. May 2, 2000. Archived from the original on 9 June 2010. Retrieved 12 February 2010.
  12. "Roderick MacKinnon". Gairdner Award. Archived from the original on 1 August 2009. Retrieved 16 February 2010.
  13. "Dean's Lecture Series Presents Nobel Laureate and Renowned Public Policy Analyst". Columbia University. Retrieved 12 February 2010.
  14. "The Nobel Prize in Chemistry 2003". The Nobel Foundation. 2003. Retrieved 12 February 2010.

Other websites[change | change source]